Separation of Cyclic Dipeptides (Diketopiperazines) from Their Corresponding Linear Dipeptides by RP-HPLC and Method Validation
نویسندگان
چکیده
منابع مشابه
Gas-chromatographic separation of stereoisomers of dipeptides.
Synthetic dipeptides comprising mixtures of enantiomers, diastereomers, or sequential isomers were converted into their N-perfluoroacetyl dipeptide esters (perfluoroacetyl: trifluoroacetyl, pentafluoroacetyl, heptafluorobutyryl; ester: methyl, 1-propyl, 2-propyl, 2,2,2-trifluoroethyl) and analyzed by GC-MS on the chiral stationary phases Chirasil-L-Val and Lipodex-E using helium as carrier gas....
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Although it is reasonable to expect that the frequency of a generic dipeptide XY in proteins is the same of its counterpart YX, on the basis of an accurate statistical analysis of a large number of protein sequences, it appears that some dipeptides XY are considerably more frequent than their mirror images YX, referred to as antidipeptides. Given that it has been verified that this unexpected a...
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ژورنال
عنوان ژورنال: Chromatography Research International
سال: 2013
ISSN: 2090-3502,2090-3510
DOI: 10.1155/2013/310269